Npgrj_nn_1696 729..731

نویسندگان

  • Dar Meshi
  • Michael R Drew
  • Michael Saxe
  • Mark S Ansorge
  • Denis David
  • Luca Santarelli
  • Chariklia Malapani
  • Holly Moore
چکیده

Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.

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تاریخ انتشار 2006